satisfaction

Our gnawing hunger for purpose and significance can be satisfied by looking unto Jesus: by knowing Him and being united to Him.

Throughout the history of mankind, people have tried to "fill" themselves with every kind of medium. Yet only One can satisfy.
Our desires aren't necessarily bad - in fact, most are God-given - yet when they become "epi-desires" (over-desires), we put them above our need for God.
He has commanded that He is first place. No substitutes allowed.

"Some wandered in desert wastes, finding no way to a city to dwell in; hungry and thirsty,their soul fainted within them.

Then they cried to the Lord in their trouble,
and he delivered them from their distress.
He led them by a straight way till they reached a
city to dwell in.

Let them thank the Lord for his steadfast love,
for his wondrous works to the children of man!

For he satisfies the longing soul,
and the hungry soul he fills with good things."

Psalm 107: 4-9 (ESV, emphasis mine)